Method for dissolving collagen-containing skin tissues

US4210721A · kind A · utility

Inventors

• Rolf Monsheimer · Darmstadt, DE
• Ernst Pfleiderer · Weiterstadt, DE

Key dates

• Filing date: Sep 19, 1977
• Grant date: Jul 1, 1980
• Expiry date: Sep 19, 1997

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/913
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

A method for dissolving collagen-containing skin tissue by hydrolyzing said tissue in a first stage in the presence of urea with an alkaline proteinase having an activity optimum between pH 9 and 13, said hydrolysis proceeding in a hydrolysis medium which is initially in the pH region optimum for the enzyme employed, and optionally further hydrolyzing said tissue in at least one further stage by adding a weakly alkaline, neutral, or acid proteinase to said hydrolysis medium.