Nucleotide inhibitor of protein synthesis
US4210746A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 10, 1978 |
| Grant date | Jul 1, 1980 |
| Priority date | — |
| Expiry date | Aug 10, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds having properties as inhibitors of protein synthesis are disclosed, of the general formula EQU (p).sub.m --(5'--A--2'--p).sub.n --(A).sub.x wherein PA1 p represents the phosphate group (orthophosphate), PA1 m is 0, 2, or 3 PA1 A represents adenosine, PA1 n is from 2 to 5, PA1 x is 0 or 1, said compound containing at least three adenosine residues, the figures 5' and 2' signifying the carbon atoms of the ribose ring to which the respective phosphate groups p are attached. Compounds of particular interest are ApApA and its phosphorylated derivatives ppApApA and pppApApA. The substances may be prepared by chemical synthesis or enzymatic synthesis. They may be incorporated in liposomes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.