5-Substituted 1-(2'-Deoxy-2'-substituted-.beta.-D-arabinofuranosyl)pyrimidine nucleosides
US4211773A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 2, 1978 |
| Grant date | Jul 8, 1980 |
| Priority date | — |
| Expiry date | Oct 2, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pyrimidine nucleosides exhibiting anti-viral and anti-tumor effects have the formula ##STR1## wherein A is OR.sup.3, SR.sup.3, NR.sup.3 R.sup.4 or NHacyl wherein R.sup.3 and R.sup.4 are the same or different and are hydrogen, lower alkyl of 1 to 7 carbon atoms, aralkyl, or aryl; PA1 NHacyl is alkanoyl or aroyl amide; PA1 B is oxygen or sulfur; PA1 X is halogen, alkylsulfonyl or arylsulfonyl; PA1 Y is halogen, amino, monoalkyl- or monoaralkylamino, dialkylamino, aminomethyl, hydroxymethyl, lower alkyl, aryl, aralkyl, vinyl and substituted vinyl or ethynyl and substituted ethynyl; PA1 Z is methyne or nitrogen; PA1 R.sup.1 and R.sup.2 are the same or different and are hydrogen acyl or aroyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.