Method for producing D-.alpha.-amino acid
US4211840A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 1978 |
| Grant date | Jul 8, 1980 |
| Priority date | — |
| Expiry date | Apr 17, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P13/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
D-.alpha.-amino acids are produced by contacting a 5-substituted hydantoin with an effective amount of an enzyme capable of converting the 5-substituted hydantoin to the D-.alpha.-amino acid produced by a microorganism in an aqueous medium at a pH in the range of 4 to 9, the microorganism being capable of utilizing the D-isomer of the 5-substituted hydantoin as the sole nitrogen source, but substantially incapable of utilizing the L-isomer of the 5-substituted hydantoin as the nitrogen source and the substituent of the 5-position being such that upon reaction with the enzyme, an optically active D-.alpha.-amino acid isomer is produced; and recovering the D-.alpha.-amino acid which accumulates in the aqueous medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.