Cyclization of peptides
US4212795A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 13, 1978 |
| Grant date | Jul 15, 1980 |
| Priority date | — |
| Expiry date | Nov 13, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The synthesis of a disulfide cyclic peptide by preparing an intermediate peptide containing two cysteine moieties, each of which is protected by an n-alkylthio group, or when one of such moieties is in an amino terminal position, this one moiety may be protected by a cysteine group while the other is protected by an n-alkylthio group, and placing such intermediate peptide in a solution substantially free of oxygen and preferably at a pH of from 5 to 10 until rearrangement has taken place, to yield a cyclic disulfide peptide. The disclosure also embraces said intermediate peptides as new compounds and the processes by which they are prepared.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.