Preparation of o-dialkylaminomethylphenols
US4212822A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 30, 1976 |
| Grant date | Jul 15, 1980 |
| Priority date | — |
| Expiry date | Dec 30, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C213/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
In the preparation of an o-dialkylaminomethylphenol of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 6 carbon atoms, or R.sup.1 and R.sup.2 conjointly with the adjacent nitrogen atom, form a five-membered or six-membered ring, by reacting phenol, formaldehyde or paraformaldehyde and an amine of the formula ##STR2## the improvement which comprises carrying out the reaction in the presence of an organic liquid which is immiscible with water but which is a solvent for the phenol and amine employed as starting materials and the o-dialkylaminomethylphenol which is formed. Advantageously the amine is dimethylamine or diethylamine, the organic liquid is a member selected from the group consisting of cyclohexane, methylcyclohexane, methylene chloride, chloroform, carbon tetrachloride, ethylene chloride, diethyl ether, dipropyl ether, dibutyl ether, dipentyl ether, methyl butyl ether, ethyl propyl ether, diisopropyl ether and di-isobutyl ether, the reaction is effected at about 10.degree. to 70.degree. C., about 1.1 to 2 moles of phenol, about 1 mole of formaldehyde and about 2.5 to 3.5 moles of the organic liquid, after the reaction the by-product …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.