Preparation of cyclopentane-1,1-diacetic acid and intermediate
US4212973A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 1, 1979 |
| Grant date | Jul 15, 1980 |
| Priority date | — |
| Expiry date | Aug 1, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C53/134
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed is a process comprising reacting the reaction product of cyclopentanone and methyl cyanoacetate with cyanoacetamide and/or the reaction product of cyclopentanone and cyanoacetamide with methyl cyanoacetate, in the presence of a basic catalyst, to give the intermediate .beta.,.beta.-tetramethylene-.alpha.,.alpha.'-dicyanoglutarim ide, or its salt. In the process, the said reaction products may be formed together in the same reaction system, and the said intermediate preparation preferably is carried out between about 10.degree. C. and about 50.degree. C., in a polar, aprotic solvent, and in the presence of a basic catalyst, e.g., such as triethylamine. The intermediate may then be hydrolyzed to the cyclopentane-1,1-diacetic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.