Process for preparing high-melting chenodeoxycholic acid
US4213911A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 7, 1978 |
| Grant date | Jul 22, 1980 |
| Priority date | — |
| Expiry date | Nov 7, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J9/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing a high-melting form of CDCA having a melting point of at least about 160.degree. C. is disclosed which comprises the steps of: PA1 (a) suspending at least one form of CDCA having a melting point of below 160.degree. C. in a non-aromatic liquid hydrocarbon, preferably cyclohexane, to form a suspension having a boiling point of at least 65.degree. C.; PA1 (b) heating the suspension to a sufficiently high temperature of between about 65.degree. and about 140.degree. C., preferably between about 75.degree. and about 100.degree. C., during a sufficiently long period of time for converting substantially all of the CDCA into the high-melting form; PA1 (c) recovering the high-melting form of CDCA from the suspension. Low-melting amorphous and/or crystalline forms of CDCA, as well as CDCA-solvent inclusion complexes can be treated in the above-described process. The high-melting CDCA is obtained in form of a substantially granular powder, which is suitable to be formulated into therapeutical compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.