Novel derivatives of imidazole and pharmaceutical compositions containing them and method of use

US4213986A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Ulrich Gebert · Königstein, DE
• Josef Musil · Königstein, DE
• Rolf-Ortwin Weber · Niedernhausen, DE

Key dates

• Filing date: Oct 6, 1978
• Grant date: Jul 22, 1980
• Expiry date: Oct 6, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A physiologically-acceptable compound of one of the formulae ##STR1## wherein R.sup.1 is a member selected from the group consisting of (a) a 6-membered heteroaromatic ring with up to two ring hetero atoms selected from the group consisting of O, N and S, at most one of which is different from nitrogen, and (b) an alkyl group containing from 1 to 4 carbon atoms and substituted by such a heteroaromatic ring; PA1 each of R.sup.2 and R.sup.3 is, independently, a hydrogen atom, alkyl having up to 4 carbon atoms, substituted or unsubstituted aryl or, together with the other of R.sup.2 and R.sup.3, unsubstituted --CH.dbd.CH--CH.dbd.CH-- or --CH.dbd.CH--CH.dbd.CH-- substituted by a member selected from the group consisting of alkyl having up to 4 carbon atoms, alkoxy having up to 4 carbon atoms, haloalkyl having up to 4 carbon atoms, halo and nitro; PA1 R.sup.4 is a member selected from the group consisting of a hydrogen atom, alkyl having up to 4 carbon atoms, aryl and aralkyl having up to 4 carbon atoms in the alkyl moiety; and PA1 A is a single bond or alkylene having from 1 to 6 carbon atoms; any substituent of substituted aryl being a member selected from the group consisting of alky…