Aromatic piperazinyl substituted dihydrouracils

US4216216A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Rolf-Ortwin Weber · Niedernhausen, DE
• Hiristo Anagnostopulos · Wiesbaden, DE
• Ulrich Gebert · Königstein, DE

Key dates

• Filing date: Jun 15, 1978
• Grant date: Aug 5, 1980
• Expiry date: Jun 15, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of general formula ##STR1## are disclosed wherein appropriate substituents for R.sup.1, R.sup.2 to R.sup.5, R.sup.6, A, Q, X, and Z are defined for these novel hexahydropyrimidines. Procedures for the preparation of these compounds are also given. Because of the highly effective serotonin antagonistic activity in combination with a strong inhibiting effect on thrombocyte aggregation and good compatibility these compounds are effective in treating migraine. Additionally, the compounds also exhibit an anti-histamine activity, cause an increase in erythrocyte fluidity, a psychotropic activity, a weak bradykinin antagonism and hypotensive effects.