Synthesis of steroids
US4217279A · kind A · utility
Inventor
Key dates
| Filing date | Dec 18, 1978 |
| Grant date | Aug 12, 1980 |
| Priority date | — |
| Expiry date | Dec 18, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0094
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The synthesis of 25-hydroxycholesterol and 1.alpha.,25-dihydroxycholesterol in which the sterol nucleus of an ester of hyodeoxycholic acid is stabilized by protection of the 3 and 6.alpha.-hydroxyl groups with alkyl groups, alkyl ether groups, preferably with the 3.beta.-methoxyethoxymethyl group or with the heterocyclic 2-tetrahydropyran group, then extending the chain from the carbon at the 24-position to a cyanide group at the 25-position and then subjecting the sterol so formed to a series of reactions by which it is transformed into 1.alpha.,25-dihydroxycholesterol or by a modified series of reactions to 25-hydroxycholesterol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.