N-.alpha.Methylcyclopropylmethyl derivatives of normorphine and noroodeine, and analgesic compositions and methods employing the normorphine derivatives
US4218454A · kind A · utility
12Cited by
5References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 24, 1978 |
| Grant date | Aug 19, 1980 |
| Priority date | — |
| Expiry date | May 24, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel N-sec-alkyl derivatives of norcodeine and normorphine wherein the sec-alkyl group contains either four or five carbon atoms. Specifically included are those derivatives of norcodeine and normorphine wherein the sec-alkyl group is 2-butyl, 3-pentyl, .alpha.-methylallyl and .alpha.-methylcyclopropylmethyl. The normorphine derivatives have strong agonist potency combined with strong antagonist qualities and indicated low addiction potential. The norcodeine analogs are useful as intermediates in preparing the corresponding normorphine compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.