Patent · US Expired

Epinine esters and pharmaceutical compositions thereof

US4218470A · kind A · utility

8Cited by

4References

6Claims

0Family size

Assignee

SIMES Societa Italiana Medicinali e Sintetici S.p.A. · IT

Inventors

Cesare Casagrande · Arese, IT
Giorgio Ferrari · Milano, IT

Key dates

Filing date	Jul 28, 1977
Grant date	Aug 19, 1980
Priority date	—
Expiry date	Jul 28, 1997

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C46/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Novel cardiocirculatory analeptics are prepared, which are epinine esters as obtained by reacting epinine (N-methyldopamine) with branched-chain aliphatic carboxylic acids. Exemplary members are 3,4-di-O-butyrylepinine and 3,4-di-O-pivaloylepinine. These medicaments are effective also by the oral route of administration, contrary to the hitherto commonly used dopamine derivatives which are rapidly destroyed by metabolization when administered orally.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.