Primary aminoacylanilides, methods of making the same and use as antiarrhythmic drugs
US4218477A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1976 |
| Grant date | Aug 19, 1980 |
| Priority date | — |
| Expiry date | Jan 22, 1996 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/165
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Primary amino acylanilides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R.sub.2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.3 is selected from the group consisting of hydrogen and methyl, R.sub.4 is selected from the group consisting of hydrogen, methyl, and a C.sub.1 -C.sub.4 alkoxy group, R.sub.6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R.sub.7 is hydrogen, methyl or ethyl, R.sub.8 is hydrogen, R.sub.9 is hydrogen, methyl or ethyl, R.sub.10 is hydrogen, and n is 0 or 1, with the provisions that PA1 (a) when n is 0, R.sub.8 can also be methyl; PA1 (b) when n is 1, and R.sub.7 is hydrogen, and R.sub.9 is hydrogen or methyl, then R.sub.10 can also be methyl; PA1 (c) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3 is hydrogen, R.sub.6 is methyl, R.sub.7 is hydrogen, R.sub.8 is hydrogen, and n is 0, then R.sub.4 can be ethoxy or propoxy only; PA1 (d) when R.sub.1 is hydrogen, R.sub.2 is methyl, R.sub.3, R.sub.4, R.sub.7 and R.sub.8 are hydrogen, and n is 0, then R.sub.6 is methoxy, ethoxy, or ethyl only; PA1 and the t…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.