Process for the preparation of garamine and garamine derivatives

US4218561A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Hans Paulsen · Hamburg, DE
• Peter Stadler · Haan, DE
• Polkhard Iodter · Hamburg, DE

Key dates

• Filing date: Oct 20, 1977
• Grant date: Aug 19, 1980
• Expiry date: Oct 20, 1997

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of garamine and garamine derivatives of the formula (I) ##STR1## wherein the radicals R.sup.1 are each H or amino-protecting groups and the radicals R.sup.2 are each H or hydroxyl-protecting groups, comprises selectively cleaving in a strong acid a compound of formula (II) or a mixture thereof ##STR2## wherein R.sup.3 is acyl, R.sup.4 and R.sup.5 are each H or CH.sub.3 and R.sup.1 and R.sup.2 are the same as in formula (I).