Vasoactive lung polypeptides
US4220642A · kind A · utility
Inventors
Key dates
| Filing date | Sep 7, 1978 |
| Grant date | Sep 2, 1980 |
| Priority date | — |
| Expiry date | Sep 7, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/848
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vasoactive polypeptide fractions having biological activity isolated in purified form from animal lungs induce peripheral vasodilation and systemic hypotension. One of the peptides exhibits the property of relaxing isolated non-vascular smooth muscle organs while the other peptide contracted these tissues. The peptide fractions are obtained from the lungs of animals by procedures invloving boiling and mincing the lung, extracting the peptides into acetic acid, adsorbing by alginic acid, eluting with HCl and salting out, extracting into alchol, again adsorbed with alginic acid, fractionating by gel chromatography, e.g. on Sephadex G-25, and by ion exchange chromatography, e.g. on carboxymethyl cellulose, followed by further ion exchange chromatography and, optionally, countercurrent distribution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.