Sampling and determination of diffusible chemical substances
US4221567A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 23, 1977 |
| Grant date | Sep 9, 1980 |
| Priority date | — |
| Expiry date | Dec 23, 1997 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/4925
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Method and system for sampling and determining chemical substances such as blood gases, in a fluid matrix, such as blood, by bringing the chemical substances into equilibrium with a liquid in a fiber probe, passing the equilibrated liquid to a sensor adjacent the equilibrium region and on into a hollow fiber line enclosed in a calibration chamber. Calibration of the sensors is accomplished by reversing the flow of liquid from the hollow fiber line to the sensors. In the system chemical substances for sensor calibration are provided by an electric proportioner whose output is continuously controlled by the output of the sensors such that the substances proportioned into a fluid in the calibration chamber surrounding the hollow fiber line are substantially the same as the substances within the matrix. The concentration of substances is determined by the output of the sensors and the amount of substances fed from the proportioner to the fluid surrounding the hollow fiber line. When the substances being measured are in equilibrium with both the matrix and fluid surrounding the hollow fiber line, a null response is obtained at the sensors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.