2-(Optionally-substituted)benzylperhydroazepines for analgesia and lowering blood pressure

US4221788A · kind A · utility

Assignee

• Byk Gulden Lomberg Chemische Fabrik GmbH · DE

Inventor

• Klaus Eistetter · Konstanz, DE

Key dates

• Filing date: Jul 27, 1977
• Grant date: Sep 9, 1980
• Expiry date: Jul 27, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D223/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Title compounds and their acid-addition salts are physiologically acceptable or are readily converted to physiologically-acceptable counterparts by established procedures. They are pharmacologically active on the central nervous system (CNS) and are thus useful, when administered to warm-blooded animals, to induce central stimulation, to increase vigilance and to promote normal and pathologically-inhibited drive. They are also useful as analgesics and as blood-pressure-reducing agents for warm-blooded animals. These compounds are prepared, e.g., by reducing an appropriate 2-benzylazacycloheptane and are compounded into normal dosage-form medicament compositions.