Lactam-N-acetic acids and their amides

US4221789A · kind A · utility

Assignee

• UCB, Inc. · BE

Inventors

• Ludovic Rodriguez · Brussels, BE
• Lucien Marchal · Braine-l'Alleud, BE

Key dates

• Filing date: May 7, 1979
• Grant date: Sep 9, 1980
• Expiry date: May 7, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D227/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New lactam-N-acetic acids and amides thereof having the formula ##STR1## wherein R.sub.1 and R.sub.2 =H, C.sub.1 -C.sub.4 -alkyl, aryl or halogen-substituted aryl, PA1 R.sub.3 =OH or --NR.sub.4 R.sub.5, PA1 R.sub.4 and R.sub.5 =H, C.sub.1 -C.sub.4 -alkyl, cycloalkyl, aralkyl or, taken together with the N atom form alkyleneimino, oxa-alkyleneimino, aza-alkyleneimino or N-benzyl-aza-alkyleneimino, PA1 m is 3, 4 or 5, preferably 3, PA1 n is 0, 1 or 2, preferably 2; and the pharmaceutically acceptable salts of said acids. Processes for producing these compounds and pharmaceutical compositions containing the same are also given. These compounds show amongst others beneficial activity on the mnemic processes and cardiac activity.