Substituted dibenzyl ethers and pharmaceutical compositions containing said ethers for the treatment of infections
US4221803A · kind A · utility
4Cited by
2References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 9, 1979 |
| Grant date | Sep 9, 1980 |
| Priority date | — |
| Expiry date | May 9, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are provided 2,4-dichloro-4'-phenyl-.alpha.-(N-imidazolyl-methyl)-dibenzyl ether, 2,4-dichloro-4'-phenylthio-.alpha.-(N-imidazolyl-methyl)-dibenzyl ether and pharmaceutically acceptable acid addition salts thereof. These compounds show activity against some fungi, yeasts and gram positive aerobic and anaerobic bacteria. The new compounds can be prepared by condensing 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)-ethanol with 4-chloromethyl-biphenyl, 4-bromomethyl-biphenyl, 1-phenylthio-4-chloromethyl-benzene or 1-phenylthio-4-bromomethyl-benzene in a solvent, most preferably dimethylsulphoxide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.