Peptides
US4223016A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 29, 1978 |
| Grant date | Sep 16, 1980 |
| Priority date | — |
| Expiry date | Jun 29, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptides (6-12 amino acids) and their salts, useful in allergy desensitization compositions, particularly vaccines, have the formula EQU X--R--R.sub.1 --R.sub.2 --R.sub.3 --Y where R is optional and, if present, is a group resistant to enzyme hydrolysis; R.sub.1 is a basic amino acid residue optionally linked to basic and/or neutral nonhydrophobic amino acid residues; R.sub.2 is one or more neutral nonhydrophobic amino acid residues; R.sub.3 is one or more hydrophobic amino acid residues optionally linked to neutral nonhydrophobic amino acid residues; X is hydrogen or an N-protecting group; and Y is hydroxyl or a C-terminal protecting group. Examples are: PA1 Lys Thr Lys Gly Ser Gly Phe Phe OCH.sub.3 PA1 Arg Lys Thr Lys Gly Ser Gly Phe Phe OCH.sub.3 PA1 Lys Thr Lys Gly Ser Gly Phe Phe Val Phe OCH.sub.3 PA1 Lys Thr Lys Gly Ser Gly Phe Phe Val Phe OH PA1 Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe OCH.sub.3 PA1 Lys Thr Lys Gly Ser Gly Phe Phe OH
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.