Process for preparing cephalosporin antibiotics
US4223134A · kind A · utility
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3Claims
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Key dates
| Filing date | Nov 28, 1978 |
| Grant date | Sep 16, 1980 |
| Priority date | — |
| Expiry date | Nov 28, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The silylated and enamine protected D-3- or 4-hydroxyphenylglycine as the sodium salt of the formula ##STR1## wherein A is methyl or ethyl, are crystalline intermediates useful in a new process for the acylation of heterocyclicthiomethyl-substituted cephalosporin nuclei, e.g. 7-amino-3-(5-methyl-1,3,4-thiadiazole-2-ylthiomethyl)-3-cephem-4-carboxyli c acid and 7-amino-3-(1-methyl-1H-tetrazole-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.