Method and apparatus for monitoring metabolism in body organs in vivo
US4223680A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 5, 1979 |
| Grant date | Sep 23, 1980 |
| Priority date | — |
| Expiry date | Mar 5, 1999 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/0004
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A spectrophotometric method, apparatus and reflectance technique is directed to non-invasive, harmless, continuous, atraumatic, in vivo, in situ monitoring of metabolism in a body organ utilizing measuring and reference wavelengths within the near infrared region, i.e., 700-1300 nm. Monitoring of oxidative metabolism is accomplished by monitoring oxygen sufficiency in an organ, normally an internal vital organ, e.g., the brain or heart, of a living human or animal body. Advantage is taken of the critical characteristic of cellular enzyme cytochrome a, a.sub.3 within the optical path and within the radiated portion of the selected organ from which the light so reflected for absorbing the selected measuring wavelength and for light of this measuring wavelength, as well as at least one reference wavelength within the same defined infrared region and at a low, non-hazardous level of intensity to travel to the organ, be reflected and be detectable at a point spaced from the point of entry and at the end of a relatively long path, e.g., of several centimeters length, which may include substantial content of bone as well as soft tissue. The method corrects for skin blood flow effects, var…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.