Process for the production of N-substituted .alpha.-ketocarboxylic acid amides

US4224226A · kind A · utility

Assignee

• Deutsche Gold- und Silber-Scheideanstalt Vormals Roessler

Inventors

• Axel Kleemann · Hanau, DE
• Herbert Klenk · Hanau, DE
• Heribert Offermanns · Hanau, DE
• Paul Scherberich · Konstanz, DE
• Werner Schwarze · Frankfurt, DE

Key dates

• Filing date: Jul 20, 1978
• Grant date: Sep 23, 1980
• Expiry date: Jul 20, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/54
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds are prepared of the formula ##STR1## where R' is a t-alkyl group having 4 to 18 carbon atoms, preferably t-butyl, t-amyl or t-octyl and R is a straight or branched chain alkyl group with 1 to 18 carbon atoms, preferably 1 to 10 carbon atoms or an alkyl group substituted with one or more phenyl groups or a halogen atom, particularly a chlorine atom, or a cycloalkyl group with 3 to 8 carbon atoms, particularly cyclopropyl, which can be substituted by one or more 1 to 3 carbon atom alkyl groups or one or more halogen atoms, preferably chlorine, or phenyl or naphthyl or a five membered heterocyclic group or such phenyl, naphthyl or heterocyclic group substituted by halogen atoms, nitro groups, alkyl or alkoxy with 1 to 5 carbon atoms by condensing in acid medium an acyl cyanide of the formula EQU R--CO--CN (II) where R is as defined above with either PA1 (a) a tertiary alcohol of the formula EQU HO--R' (III) PA1 in which R' is as defined above, or preferably PA1 (b) an alkene of the formula ##STR2## where R.sub.1 and R.sub.2 are the same or different and are hydrogen or an alkyl group and wherein R.sub.3 and R.sub.4 are the same or different and wherein the alkyl groups in ea…