Process for preparing hydrogels as spherical beads of large size
US4224427A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 1, 1978 |
| Grant date | Sep 23, 1980 |
| Priority date | — |
| Expiry date | Jun 1, 1998 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S526/93
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure describes an improved process for the preparation of uniform, spherical beads of up to 5 mm diameter of a crosslinked, water-insoluble hydrogel by suspension polymerization in a concentrated aqueous salt solution of 95-30% by weight of a monoolefinic water-soluble monomer containing at least 5% of a hydroxy substituted hydrophilic vinyl monomer with 5-70% by weight of a terminal diolefinic macromer crosslinking agent in the presence of water-insoluble, gelatinous, strong water-bonding inorganic metal hydroxides as suspending agents in the absence of excess alkali. The hydrogels have a host of pharmaceutical and industrial uses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.