Daunorubicin derivatives
US4225589A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 9, 1977 |
| Grant date | Sep 30, 1980 |
| Priority date | — |
| Expiry date | Nov 9, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D327/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Daunorubicin derivatives of the formula: ##STR1## wherein R.sub.1 represents a group of the formula: ##STR2## in which (i) X.sub.1 and X.sub.2 both represent oxygen or both represent sulphur and the symbols R.sub.3 each represent alkyl of 1 through 4 carbon atoms, phenyl or phenyl substituted in the para-position by methyl, methoxy or methylthio, or together form an alkylene radical of 2 through 4 carbon atoms, or (ii) one of X.sub.1 and X.sub.2 represents oxygen and the other represents sulphur and the symbols R.sub.3 together form an alkylene radical of 2 through 4 carbon atoms, and R.sub.4 represents hydrogen, alkyl of 1 through 4 carbon atoms or phenyl, and R.sub.2 represents hydrogen or trifluoroacetyl, are new compounds possessing anti-tumour properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.