Substituted fluoracylresorcinols

US4225619A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Rolf-Stefan Brickl
• Hans-Frieder Eberhardt · Biberach, DE
• Karl-Richard Appel · Biberach, DE
• Uwe Lechner · Biberach an der Riß, DE
• Walter Merk · Biberach an der Riß, DE

Key dates

• Filing date: Mar 19, 1979
• Grant date: Sep 30, 1980
• Expiry date: Mar 19, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q5/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is perfluoroalkyl of 1 to 8 carbon atoms or 2,2,3,3-tetrafluoro-cyclobutyl, PA1 R.sub.2 and R.sub.4, which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 10 carbon atoms, aliphatic acyl of 2 to 18 carbon atoms, benzoyl, salicyloyl or phenylacetyl, and PA1 R.sub.3 and R.sub.5, which may be identical to or different from each other, are each alkyl of 3 to 18 carbon atoms, halogen, nitro, p-toluenesulfonyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclododecyl, methylcyclohexyl, dimethylcyclohexyl, benzyl, methylthio or ##STR2## where R.sub.1, R.sub.2 and R.sub.4 have the meanings previously defined, PA2 Q is --CH.sub.2 -- or --S--, and PA2 G is R.sub.5, as above defined, or PA2 Q is R.sub.3, as above defined, and PA2 G is --CH.sub.2 -- or --S--, PA1 R.sub.3 may, in addition, also be hydroxyl, methoxy, methyl or cyano, and PA1 R.sub.5 may also be methyl, or one of substituents R.sub.3 and R.sub.5 is hydrogen or ethyl when the other has the meanings defined above except hydrogen, or when R.sub.1 has the meanings defined above except trifluoromethyl, or when R.sub.2 and R.sub.4 have the meanings defined a…