Patent · US Expired

Process for producing new ansamycin antibiotic

US4225674A · kind A · utility

4Cited by

3References

1Claims

0Family size

Assignee

PFIZER INC. · US

Inventors

Walter D. Celmer · New London, US
Walter P. Cullen · East Lyme, US
John R. Oscarson · Pawcatuck, US
Liang H. Huang · Mesa, US
Riichiro Shibakawa · Handa, JP
Junsuke Tone · Chita, JP

Key dates

Filing date	Apr 30, 1979
Grant date	Sep 30, 1980
Priority date	—
Expiry date	Apr 30, 1999

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S435/886
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A new subspecies of Streptomyces nigellus Prokop, designated Streptomyces nigellus Prokop subsp. africanus Huang subsp. nov. ATCC 31496, when propagated under aerobic conditions in aqueous nutrient media, produces a mixture of antibiotics. One of these antibiotics is the known macrolide antibiotic cirramycin A; the ansamycin antibiotic is an analogue of protostreptovaricin and the structure has been established as 21-hydroxy, 25-demethyl, 25-methylthioprotostreptovaricin I.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.