Aminopropanol substituted indole compounds and compositions for the treatment of cardiac and circulatory diseases

US4229464A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfgang Kampe
• Kurt Stach
• by Werner Plattner, administrator · Linz, AT
• Max Thiel
• Wolfgang Bartsch · Viernheim, DE
• Karl Dietmann
• Egon Roesch · Mannheim, DE
• Wolfgang Schaumann · Heidelberg, DE

Key dates

• Filing date: Sep 18, 1978
• Grant date: Oct 21, 1980
• Expiry date: Sep 18, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl, PA1 R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, and PA1 R.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.