Preparation of 1-azolyl-3,3-dimethyl-1-phenoxy-butan-2-ones

US4229580A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hermann Arold · Wuppertal, DE
• Hans-Ludwig Elbe · Wuppertal, DE
• Eckart Kranz
• Wolfgang Kramer · Wuppertal, DE
• Jorg Stetter · Wuppertal, DE
• Claus Stolzer
• Rudolf Thomas · Haan, DE

Key dates

• Filing date: Mar 9, 1978
• Grant date: Oct 21, 1980
• Expiry date: Mar 9, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D249/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

In the reaction of 1-chloro-3,3-dimethylbutan-2-one with a phenol to form an ether-ketone, halogenating it to form a halogenoether-ketone and reacting it with imidazole or 1,2,4-triazole to form a 1-azolyl-3,3-dimethyl-1-phenoxybutan-2-one of the formula ##STR1## in which X is N or CH, PA1 n is an integer from 0 to 4, and PA1 Y each independently is halogen, phenyl, phenoxy, nitro, alkyl, alkoxy or cycloalkyl, the improvement which comprises effecting all steps successively in an aromatic hydrocarbon or chlorinated aliphatic or aromatic hydrocarbon as solvent without intermediate isolation. The products are obtained in high yield.