Drug excipient of silicone rubber
US4230686A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 23, 1976 |
| Grant date | Oct 28, 1980 |
| Priority date | — |
| Expiry date | Dec 23, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G77/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nontoxic sustained release pharmaceutical compositions containing one or more nonionic, lipophilic drugs in a cured low temperature vulcanizable (LTV) silicone elastomer excipient are prepared substantially free of toxic vulcanizing agents or drug-reactive by-products in the elastomeric material by curing an admixture of the drug or drug containing core, LTV-methylvinylsiloxane units containing linear dimethylpolysiloxane and a dimethylpolysiloxane crosslinking composition containing silicon linked H atoms using a noble metal-based catalyst. The resultant compositions are characterized by good physical properties and a constant rate of drug release in the body over long periods of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.