Antacid tablets and processes for their preparation

US4230693A · kind A · utility

Assignee

• Armour-Dial, Inc. · US

Inventors

• Henry J. Izzo · Bound Brook, US
• Martin Moran · Wethersfield, US
• Frederick G. Wheeler · Poplarville, US

Key dates

• Filing date: Dec 3, 1976
• Grant date: Oct 28, 1980
• Expiry date: Dec 3, 1996

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K33/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An antacid tablet is prepared which contains a combination of an antacid ingredient, sugar, and fat and which has a hardness requiring no more than 9 pounds peak force to cause a blunt probe to penetrate its surface. Included also are processes for preparing such a tablet in which an antacid ingredient, sugar, and melted fat are mixed, cooled and milled to produce a powdered mixture, and the mixture formed into tablets. Further improvements include using a fine sugar, 90% of which will pass a 200 mesh screen; maintaining the plungers and dies of the tableting machine above the melting point of the fat; and utilizing a limited pressure (50 to 600 pounds per square inch) in the compressing of the tablets. Another feature involves controlling the moisture to within 3 to 10% based on the weight of the tablet.