7-Methyl-8.beta.-lower alkyl or 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds and therapeutic method of treating pain employing them
US4230712A · kind A · utility
13Cited by
5References
44Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 21, 1979 |
| Grant date | Oct 28, 1980 |
| Priority date | — |
| Expiry date | May 21, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D221/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are 7-methyl, 8.beta.-lower alkyl and 7 methyl-8-lower alkyl substituted B/C Cis or Trans morphinan-6-one compounds characterized by the structural formula: ##STR1## Specific compounds, included within the scope of the foregoing general formula wherein R.sub.1 is H or methyl, R.sub.2 is cyclopropylmethyl or cyclobutylmethyl, R.sub.3 is H, methyl, ethyl or n-propyl and R.sub.4 is H or methyl are useful as mixed analgesics/narcotic antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.