Aminoglycoside antibiotic compounds
US4230847A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 18, 1978 |
| Grant date | Oct 28, 1980 |
| Priority date | — |
| Expiry date | May 18, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H23/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Selective blocking of some amino groups in a polyamino organic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and hydroxyl group pairs in said polyamino organic compound, followed by introduction of blocking groups on the non-complexed amino groups and, finally, removing the transition metal cations from the selectively N-blocked polyamino organic compound complex to obtain a polyamino organic compound having selectively blocked amino groups. This process is particularly valuable when carrying out aminocyclitol-aminoglycoside transformations utilizing transition metal salt complexes of cupric acetate, nickel (II) acetate, cobalt (II) acetate or mixtures thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.