.omega.-Halo-PGI.sub.2 analogues
US4232009A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 22, 1979 |
| Grant date | Nov 4, 1980 |
| Priority date | — |
| Expiry date | Feb 22, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C405/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Prostaglandin I.sub.2 analogues of the formula: ##STR1## [wherein Y represents ethylene or trans-vinylene, R.sup.1 represents hydrogen, alkyl of 1 to 12 carbon atoms, aralkyl of 7 to 12 carbon atoms, cycloalkyl of 4 to 7 carbon atoms optionally substituted by at least one alkyl group containing from 1 to 4 carbon atoms, phenyl unsubstituted or substituted by at least one chlorine atom, trifluoromethyl group, alkyl group containing from 1 to 4 carbon atoms or phenyl group, a --C.sub.m H.sub.2m COOR.sup.4 group (wherein m is an integer from 1 to 12 and R.sup.4 represents alkyl of 1 to 4 carbon atoms), a C.sub.n H.sub.2n OR.sup.5 group (wherein n is an integer from 2 to 12 and R.sup.5 represents hydrogen or alkyl of 1 to 4 carbon atoms), or a ##STR2## (wherein n is as hereinbefore defined and R.sup.6 and R.sup.7 each represent alkyl of 1 to 4 carbon atoms), R.sup.2 represents hydrogen, methyl or ethyl, X represents a --C.sub.p H.sub.2p --group (wherein p is an integer from 2 to 8) or a ##STR3## (wherein R.sup.8 represents a single bond, or alkylene of 1 to 4 carbon atoms, R.sup.9 represents a single bond or alkylene of 1 to 8 carbon atoms, and q is an integer from 3 to 6), R.sup.3 rep…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.