Patent · US Expired

10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines

US4232158A · kind A · utility

8Cited by
10References
2Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJun 4, 1979
Grant dateNov 4, 1980
Priority date—
Expiry dateJun 4, 1999

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY02P20/55
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease. They are prepared by treatment of a 5H-dibenzo[a,d]cyclohepten-5-one with ammonia to give the 5-imine, acylation of the imine, treatment of the protected imine with an organolithium to provide the 5-substituted-5-acylamino compound, treatment with acid or base to cause ring closure to a 5-substituted-5,10-acylimino compound followed by removal of the protecting group, either hydrolytically or hydrogenolytically.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.