Patent · US Expired

Pyroglutamic acid derivatives and analogs

US4234489A · kind A · utility

30Cited by

2References

17Claims

0Family size

Assignee

E.R. SQUIBB & SONS. INC. · US

Inventors

Miguel A. Ondetti · Princeton, US
Eric M. Gordon · Pennington, US
Denis E. Ryono · Princeton, US

Key dates

Filing date	Jun 25, 1979
Grant date	Nov 18, 1980
Priority date	—
Expiry date	Jun 25, 1999

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D207/28
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Pyroglutamic acid derivatives and analogs having the formula ##STR1## and salts thereof, wherein R is hydrogen, alkyl or diphenylmethyl; PA1 R.sub.1 is hydrogen, alkyl or trifluoromethyl; PA1 R.sub.2 is hydrogen, ##STR2## or ##STR3## R.sub.3 is hydrogen, alkyl, phenyl, or phenylalkyl; X is oxygen or sulfur; and PA1 n is 0 or 1; have useful hypotensive activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.