Production of aldehyde-treated allergen-containing substances
US4234569A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 4, 1978 |
| Grant date | Nov 18, 1980 |
| Priority date | — |
| Expiry date | Oct 4, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/35
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to a method of production of formaldehyde, and lower saturated aliphatic dialdehyde-treated allergens suitable for the immunotherapy (desensitization) of individuals suffering from allergies of the immediate type in a plurality of steps wherein said formaldehyde and/or said dialdehyde is utilized alone or in combination for the modification of allergen-containing materials. These lower saturated aliphatic mono- and dialdehyde treated allergen-containing materials are useful in ameliorating the symptoms of allergic (atopic) people. Also, they are able to induce formation of blocking antibody in mammals which cross-reacts with the native allergen-containing materials. Reactions with formaldehyde are carried out in a non-phenolic environment in a plurality of steps. The reaction involving combinations of aldehydes can be carried out in a single step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.