Penicillanic acid 1,1-dioxides as .beta.-lactamase inhibitors
US4234579A · kind A · utility
46Cited by
7References
26Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 5, 1979 |
| Grant date | Nov 18, 1980 |
| Priority date | — |
| Expiry date | Mar 5, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Penicillanic acid 1,1-dioxide, and esters thereof readily hydrolyzable in vivo, are useful as antibacterial agents, and also for enhancing the effectiveness of several .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria. Derivatives of penicillanic acid 1,1-dioxide having the carboxy group protected by a conventional penicillin carboxy protecting group are useful intermediates to penicillanic acid 1,1-dioxide. Penicillanic acid 1-oxides and certain esters thereof are useful chemical intermediates to penicillanic acid 1,1-dioxide and its esters.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.