1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the preparation thereof
US4235803A · kind A · utility
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Key dates
| Filing date | Apr 26, 1979 |
| Grant date | Nov 25, 1980 |
| Priority date | — |
| Expiry date | Apr 26, 1999 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to 1,6-dimesyl-3,4-dimethyl-D-mannitol of the formula (I), ##STR1## wherein Ms is mesyl and Me is methyl. This compound is a potent cytostatic agent which can be used to advantage in the therapy of various tumorous diseases. 1,6-Dimesyl-3,4-dimethyl-D-mannitol is prepared according to the invention by subjecting 3,4-dimethyl-D-mannitol to partial mesylation followed by acylation, and splitting off the acyl groups of the resulting compound of the general formula (III), ##STR2## wherein Ms and Me are as defined above and R is a saturated lower aliphatic group, with an acidic alcohol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.