.beta.Adrenergic blocking piperidino ureas and thioureas

US4235915A · kind A · utility

Assignee

• John Wyeth & Brother Limited · GB

Inventors

• John L. Archibald
• Terence J. Ward

Key dates

• Filing date: Dec 5, 1977
• Grant date: Nov 25, 1980
• Expiry date: Dec 5, 1997

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D319/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula ##STR1## in which X represents oxygen or sulphur; PA0 Y represents --CHOH-- or ##STR2## Z represents ##STR3## or a direct bond; R represents cycloalkyl group having 5 to 7 carbon atoms or an optionally substituted aryl or heteroaryl radical, or when --Z-- is a direct bond R also represents hydrogen; PA0 R.sup.1 represents hydrogen or lower alkyl. and PA0 R.sup.2 represents hydrogen, halogen, lower alkyl or lower alkoxy; or PA0 a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof, are disclosed which reduce heart rate or have hyperglycaemic activity.