Antibodies against creatinekinase-M8 and process for the production thereof

US4237044A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Uwe Wurzburg · Dieburg, DE
• Norbert Hennrich
• Hans-Dieter Orth · Emmelshausen, DE
• Hermann Lang

Key dates

• Filing date: May 8, 1979
• Grant date: Dec 2, 1980
• Expiry date: May 8, 1999

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/841
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Antibodies against the M subunit of CK isoenzymes having a molecular weight between about 130,000 and 210,000, and inhibiting the enzymatic activity of the M subunit, optionally also in the presence of CK substrates, without inactivating the enzymatic activity of the B subunit of any CK-MB which may be present, are described. A process for the production of these antibodies comprises inoculating animals with activated CK-MM and recovering the antibodies in a conventional manner.