Prostaglandin analogues

US4237131A · kind A · utility

Assignee

• Beecham Group · GB

Inventors

• Gordon Wootton · Sawbridgeworth, GB
• Richard W. Moore · Chelmsford, GB

Key dates

• Filing date: Jun 14, 1979
• Grant date: Dec 2, 1980
• Expiry date: Jun 14, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/86
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound of the formula (I): ##STR1## wherein: X is O or S; PA0 Y is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--; PA0 n is 1 to 5; PA0 R.sub.1 is hydrogen or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms; PA0 R.sub.2 is hydrogen or C.sub.1-4 alkyl; PA0 R.sub.3 is hydroxy or protected hydroxy; PA0 R.sub.4 is C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl or C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl; or PA0 R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and PA0 R.sub.5 is (CH.sub.2).sub.a NR.sub.6 R.sub.7, wherein a is 0 to 3 and R.sub.6 and R.sub.7 are hydrogen, C.sub.1-4 alkyl or phenyl C.sub.1-4 alkyl, or R.sub.6 and R.sub.7 taken with the nitrogen atom to which they are joined represent a 4 to 7 membered heterocyclic ring which may contain as sole further hetero atom one oxygen atom or one optionally C.sub.1-4 alkyl substituted nitrogen atom; allyl or propargyl; (CH.sub.2).sub.b --CO--(CH.sub.2).sub.c --CH.sub.3 wherein b+c is 1 to 5 and b is not zero; or S-R.sub.8 wherein R.sub.8 is C.sub.1-6 alkyl, phenyl, or phenyl substituted by a halogen, trifluoromethy…