4-(3-(4-Quinolyl)propyl)piperidines, their preparation and their use as medicines

US4237139A · kind A · utility

Assignee

• Pharmindustrie · FR

Inventors

• Alain A. Champseix · Orsay, FR
• Claude Gueremy · Houilles, FR
• Gerard R. Le Fur · Le Plessis-Robinson, FR

Key dates

• Filing date: Dec 12, 1978
• Grant date: Dec 2, 1980
• Expiry date: Dec 12, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pharmaceutical preparations containing as active ingredient a compound having the formula: ##STR1## wherein R represents hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; and X represents hydrogen, alkyl, alkoxy or alkylthio, the alkyl groups of each containing 1 to 4 carbon atoms, halogen (chlorine, fluorine, bromine or iodine), trifluoromethyl, nitro, hydroxy, amino or amino substituted by one or two alkyl groups or by acyl or alkylsulphonyl, the alkyl groups of each containing 1 to 4 carbon atoms, which are particularly advantageous for the treatment of pathological states caused by a disturbance in the functioning of the serotoninergical systems in mammals. These preparations may also be used as anxiolytics.