2-(Pyridyl-amino)-benzoic acids and salts thereof

US4241068A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Kurt Schromm · Ingelheim am Rhein, DE
• Anton Mentrup · Mainz, DE
• Ernst-Otto Renth · Ingelheim am Rhein, DE
• Armin Fugner · Gau-Algesheim, DE
• Volker Jacobi · Gau-Algesheim, DE

Key dates

• Filing date: Aug 7, 1979
• Grant date: Dec 23, 1980
• Expiry date: Aug 7, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein A is .dbd.CH-- or .dbd.N--; PA1 R.sub.1 is (a) hydrogen, lower alkyl, lower alkoxy or a fused benzene ring, or (b) --CO--R.sub.4, tetrazol-5-yl or cyano in the 4- or 5-position; PA1 R.sub.2 is --CO--R.sub.4, tetrazol-5-yl, cyano or, when R.sub.1 has one of the meanings included in (b), also hydrogen, lower alkyl, lower alkoxy or a fused benzene ring; PA1 R.sub.3 is hydrogen or lower alkanoyl; and PA1 R.sub.4 is hydroxyl, amino, hydroxy-amino, tetrazol-5-yl-amino or lower alkoxy; internal salts thereof, and non-toxic salts thereof formed with a basic substance. The compounds as well as their salts are useful as antiallergics.