Patent · US Expired

Process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile

US4242274A · kind A · utility

2Cited by
2References
8Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJun 18, 1979
Grant dateDec 30, 1980
Priority date—
Expiry dateJun 18, 1999

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07C255/00
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

A process for the preparation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile. A charge mixture is prepared comprising diphenylacetonitrile, 1-(dimethylamino)-2-halopropane, a base, water, a water-immiscible organic solvent, and a quaternary salt selected from a group consisting of tetrabutylammonium halides, tetrabutylammonium hydrogen sulfate, cetyltrimethylammonium halides, benzyltriphenylphosphonium halides, and methyltrialkyl (C.sub.8 -C.sub.10) ammonium halides. The mixture is heated under an inert atmosphere to effect formation of 2,2-diphenyl-4-(dimethylamino)-pentane nitrile by reaction of diphenylacetonitrile, 1-(dimethylamino)-2-halopropane and a base.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.