Novel corticoids

US4243664A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Klaus Annen · Berlin, DE
• Henry Laurent
• Helmut Hofmeister · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Hans Wendt · Berlin, DE
• Joachim-Friedrich Kapp · Berlin, DE

Key dates

• Filing date: Mar 13, 1979
• Grant date: Jan 6, 1981
• Expiry date: Mar 13, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J31/006
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel corticoids of formula I ##STR1## wherein X is .beta.-hydroxymethylene, .beta.-fluoromethylene or carbonyl; Y is fluorine, chlorine, hydroxy, or acyloxy of 1-10 carbon atoms; and R.sub.1 is acyloxy of 1-10 carbon atoms, possess strong anti-inflammatory activity when administered topically and display only minor systemic side effects.