Benzodiazepine derivatives and process of making them

US4244869A · kind A · utility

Assignee

• Kalie-Chemie AG · DE

Inventors

• Wolfgang Milkowski
• Renke Budden · Hannover, DE
• Siegfried Funke
• Rolf Huschens · Hannover, DE
• Hans Liepmann · Hannover, DE
• Werner Stuhmer
• Horst Zeugner

Key dates

• Filing date: Mar 16, 1978
• Grant date: Jan 13, 1981
• Expiry date: Mar 16, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D243/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

1,4-Benzodiazepin of the formula ##STR1## wherein R is a low molecular straight or branched alkyl and X is halogen or trifluoromethyl, and pharmaceutically acceptable acid addition salts of these benzodiazepins. The benzodiazepins are made by heating an acyldiamine in the presence of phosphorus oxychloride at the latter's boiling point followed by reacting the resulting mixture of 7-member and 8-member compounds with an alkali metal alkoxide.