Process for the resolution of (+)- and (-)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid
US4246164A · kind A · utility
28Cited by
5References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 6, 1979 |
| Grant date | Jan 20, 1981 |
| Priority date | — |
| Expiry date | Jul 6, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/582
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The subject of the invention is a process for resolving mixtures of (+)- and (-)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid into the enantiomers thereof, characterized in that N-methyl-D-glucamine [=1-deoxy-1-(methylamino)-D-glucitol] is used as the resolving agent, so that the 6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid is converted into the corresponding diastereoisomeric N-methyl-D-glucamine salt pair which, because of very different solubilities, can be separated easily and completely with high yield.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.