1,5-Disubstituted imidazolid-4-ones

US4246273A · kind A · utility

Assignee

• Beecham Group · GB

Inventor

• Gordon Wootton · Sawbridgeworth, GB

Key dates

• Filing date: Mar 27, 1979
• Grant date: Jan 20, 1981
• Expiry date: Mar 27, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D233/86
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula (I): ##STR1## wherein: Y is --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.dbd.C-- n is 1 to 5; PA1 R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms; PA1 R.sub.2 is hydrogen, C.sub.1-4 alkyl, trifluoromethyl, or phenyl; PA1 R.sub.3 is hydroxy or protected hydroxy; PA1 R.sub.5 is hydrogen, C.sub.1-6 alkyl, phenyl or phenyl C.sub.1-6 alkyl, any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; and PA1 X is CH.sub.2 and PA1 R.sub.4 is C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl, phenyl-C.sub.1-6 alkyl or naphthyl-C.sub.1-6 alkyl, any of which groups may have one acyclic carbon-carbon bond interrupted by an oxygen atom; hydrogen, C.sub.3-8 cycloalky, phenyl or naphthyl, any of which phenyl of naphthyl moieties in R.sub.4 may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy or nitro groups; or PA1 R.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; or PA1 X is CS and PA1 R.sub.4 is …